Strategies in Reducing the Economic Burden of Preimplantation Genetic Testing for Aneuploidy (PGT-A) via Morphological and Genetic Integration: A Mini Review
Keywords:
Infertility, assisted reproductive technologies, preimplantation genetic testing for aneuploidy (PGT-A), economic burden, in vitro fertilizationAbstract
Infertility is a growing public health concern worldwide, with in vitro fertilization (IVF) is one of the most widely used treatment modalities. Preimplantation Genetic Testing for Aneuploidy (PGT-A) has emerged as a valuable tool in assisted reproductive technology (ART), to improve implantation rates and reduce the risk of miscarriage. Initially introduced in the mid-1990s with FISH-based methods, PGT-A has advanced significantly with the adoption of next-generation sequencing (NGS). Over the past two decades, it has been widely implemented in fertility clinics worlwide. However, the high cost of PGT-A continues to limit accessibility, particularly in resource-constrained settings. This mini review explores strategies to alleviate the economic burden of PGT-A, including refined patient selection, integration with morphological embryo assessment, and the emerging potential of mitochondrial DNA biomarkers. By addressing cost-effectiveness while maintaining clinical utility, these approaches may broaden access to PGT-A, ultimately improving equity and IVF outcomes.
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