Genetic Markers for Anesthesia-induced Neurotoxicity

Authors

  • Laviza Tuz Zahra Institute of Molecular Biology and Biotechnology,University of Lahore, Lahore, Pakistan Author
  • Zarish Shehzad Institute of Molecular Biology and Biotechnology,University of Lahore, Lahore, Pakistan Author
  • Ridhwan Abdul Wahab International Medical School, Management and Science University, Malaysia Author
  • Jacynta Jayaram International Medical School, Management and Science University, Malaysia Author
  • Atif Amin Baig International Medical School, Management and Science University, Malaysia Author

Keywords:

anesthesia, anesthesia-induced neurotoxicity, genetic and anesthesia

Abstract

This comprehensive review article delves into the intricate genetic basis of individual variability in anesthesia sensitivity and the associated neurotoxic effects of specific anesthetics. Investigating the interplay between genetic factors and neurotoxic responses, we explore key aspects shaping the landscape of personalized anesthesia care. The article meticulously outlines the diverse neurotoxic effects of certain anesthetics, shedding light on their implications for cognitive function and neurodevelopment. Through an in-depth analysis of gene variants linked to these neurotoxic responses, such as those within the APOE and BDNF, the review synthesizes current research findings to provide a holistic understanding of the intricate relationship between genetics and anesthesia-induced neurotoxicity. By bridging gaps in knowledge, this article aims to pave the way for future investigations and innovations in personalized anesthesia strategies, optimizing patient outcomes and minimizing potential risks.

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References

Agid, Y., Buzsáki, G., Diamond, D. M., Frackowiak, R., Giedd, J., Girault, J. A., & Weinberger, D. (2007). How can drug discovery for psychiatric disorders be improved? Nature Reviews Drug discovery, 6(3), 189-201.

Alavuk Kundović, S., Rašić, D., Popović, L., Peraica, M., & Črnjar, K. (2020). Oxidative stress under general intravenous and inhalation anaesthesia. Arhiv Za Higijenu Rada i Toksikologiju, 71(3), 169–177.

Alharbi, K. S., Almalki, W. H., Alzarea, S. I., Kazmi, I., Al-Abbasi, F. A., Afzal, O., ... & Gupta, G. (2024). Anaesthesia-induced changes in genomic expression leading to neurodegeneration. CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders), 23(4), 411-419.

Andropoulos, D. B. (2023). Neuroprotective strategies in anesthesia-induced neurotoxicity. Best Practice & Research Clinical Anaesthesiology, 37(1), 52-62.

Apai, C., Shah, R., Tran, K., & Pandya Shah, S. (2021). Anesthesia and the Developing Brain: A Review of Sevoflurane-induced Neurotoxicity in Pediatric Populations. Clinical Therapeutics, 43(4), 762–778.

Baghel, K., Srivastava, R. N., Chandra, A., Goel, S. K., Agrawal, J., Kazmi, H. R., & Raj, S. (2014). TNF-α, IL-6, and IL-8 cytokines and their association with TNF-α-308 G/A polymorphism and postoperative sepsis. Journal of Gastrointestinal Surgery, 18, 1486-1494.

Balasubramanian, M., Bhagat, H., Panda, N., Rawat, A., Kumar, A., & Shanmugam, D. S. (2018). Enzymatic Evaluation of General Anesthesia-Induced Neurotoxicity in Aneurysmal Subarachnoid Hemorrhage Patients. Journal of Neuroanaesthesiology and Critical Care, 05(1), A039.

Balasubramanian, M., Kuberan, A., Rawat, A., Dhandapani, S., Panda, N., Kumar, A., ... & Bhagat, H. (2021). Effect of general anesthetics on caspase-3 levels in patients with aneurysmal subarachnoid hemorrhage: A preliminary study. Journal of Neurosurgical Anesthesiology, 33(2), 172-176.

Baud, O., & Saint-Faust, M. (2019). Neuroinflammation in the Developing Brain: Risk Factors, Involvement of Microglial Cells, and Implication for Early Anesthesia. Anesthesia and Analgesia, 128(4), 718–725.

Belrose, J. C., & Noppens, R. R. (2019). Anesthesiology and cognitive impairment: A narrative review of current clinical literature. BMC Anesthesiology, 19(1), 241.

Bernstein, K., Hussey, H., Hussey, P., Gordo, K., & Landau, R. (2020). Neuro-anesthesiology in pregnancy. Handbook of Clinical Neurology, 171, 193-204.

Bessler, H., Shavit, Y., Mayburd, E., Smirnov, G., & Beilin, B. (2006). Postoperative pain, morphine consumption, and genetic polymorphism of IL-1β and IL-1 receptor antagonist. Neuroscience Letters, 404(1), 154–158.

Bosnjak, Z. J., Logan, S., Liu, Y., & Bai, X. (2016). Recent Insights Into Molecular Mechanisms of Propofol-Induced Developmental Neurotoxicity: Implications for the Protective Strategies. Anesthesia and Analgesia, 123(5), 1286–1296.

Ding, D., Wang, P., Jiang, Y., Zhang, X., Shi, W., & Luo, Y. (2021). Effects of Apolipoprotein Ε ε4 allele on early postoperative cognitive dysfunction after anesthesia. Der Anaesthesist, 70(1), 60–67.

Dokkedal, U., Wod, M., Thinggaard, M., Hansen, T. G., Rasmussen, L. S., Christensen, K., & Mengel-From, J. (2020). Apolipoprotein E ε4 and cognitive function after surgery in middle-aged and elderly Danish twins. European Journal of Anaesthesiology, 37(11), 984–991.

Eun, J. D., Jimenez, H., Adrien, L., Wolin, A., Marambaud, P., Davies, P., & Koppel, J. L. (2022). Anesthesia promotes acute expression of genes related to Alzheimer’s disease and latent tau aggregation in transgenic mouse models of tauopathy. Molecular Medicine, 28(1), 83.

Flexman, A. M., Abcejo, A. S., Avitsian, R., De Sloovere, V., Highton, D., Juul, N., ... & Rozet, I. (2020). Neuroanesthesia practice during the COVID-19 pandemic: Recommendations from Society for Neuroscience in Anesthesiology and Critical Care (SNACC). Journal of Neurosurgical Anesthesiology, 32.

Fodale, V., Tripodi, V. F., Penna, O., Famà, F., Squadrito, F., Mondello, E., & David, A. (2017). An update on anesthetics and impact on the brain. Expert Opinion on Drug Safety, 16(9), 997-1008.

Giarratana, A. O., Teng, S., Reddi, S., Zheng, C., Adler, D., Thakker-Varia, S., & Alder, J. (2019). BDNF Val66Met genetic polymorphism results in poor recovery following repeated mild traumatic brain injury in a mouse model and treatment with AAV-BDNF improves outcomes. Frontiers in Neurology, 10, 1175.

Graham, M. R. (2017). Clinical update regarding general anesthesia-associated neurotoxicity in infants and children. Current Opinion in Anaesthesiology, 30(6), 682–687.

yilGuo, L., Yu, Y., Xin, N., Sun, J., Chen, Y., & Yu, M. (2018). Clonidine Protects Against Neurotoxicity Induced by Sevoflurane Through NF-κB Signaling Inhibition and Proinflammatory Cytokine Release in Rats. Journal of Molecular Neuroscience, 65(4), 507–513.

Hao, X., Ou, M., Zhang, D., Zhao, W., Yang, Y., Liu, J., Yang, H., Zhu, T., Li, Y., & Zhou, C. (2020). The Effects of General Anesthetics on Synaptic Transmission. Current Neuropharmacology, 18(10), 936–965.

Haritha, D., Sarkar, S., Maitra, S., Kashyap, S., Verma, R., Satapathy, S., ... & Khanna, P. (2023). Comparative evaluation of isoflurane and desflurane for postoperative cognitive decline in elderly patients: A prospective observational pilot study. Journal of Perioperative Practice, 17504589231180737.

Huang, X., Ying, J., Yang, D., Fang, P., Wang, X., Zhou, B., ... & Hua, F. (2021). The mechanisms of sevoflurane-induced neuroinflammation. Frontiers in Aging Neuroscience, 13, 717745.

Hudson, A. E., & Hemmings, H. C., Jr. (2011). Are anaesthetics toxic to the brain? BJA: British Journal of Anaesthesia, 107(1), 30–37.

Ji, C., Ni, Q., Chen, W., Yang, Z., & Ma, D. (2019). General anesthetic neurotoxicity in the young: Mechanism and prevention. Neuroscience & Biobehavioral Reviews, 107, 883–896.

Johnson, S. C., Pan, A., Li, L., Sedensky, M., & Morgan, P. (2019). Neurotoxicity of anesthetics: Mechanisms and meaning from mouse intervention studies. Neurotoxicology and Teratology, 71, 22-31.

Kamat, P. P., Kudchadkar, S. R., & Simon, H. K. (2019). Sedative and Anesthetic Neurotoxicity in Infants and Young Children: Not Just an Operating Room Concern. The Journal of Pediatrics, 204, 285–290.

Karmarkar, S. W., Bottum, K. M., & Tischkau, S. A. (2010). Considerations for the Use of Anesthetics in Neurotoxicity Studies. Comparative Medicine, 60(4), 256–262.

Kaye, A. D., Mahakian, T., Kaye, A. J., Pham, A. A., Hart, B. M., Gennuso, S., ... & Urman, R. D. (2018). Pharmacogenomics, precision medicine, and implications for anesthesia care. Best Practice & Research Clinical Anaesthesiology, 32(2), 61-81.

Kim, J. H., Jung, H., Lee, Y., & Sohn, J. H. (2021). Surgery performed under propofol anesthesia induces cognitive impairment and amyloid pathology in ApoE4 knock-in mouse model. Frontiers in Aging Neuroscience, 13, 658860.

Koo, C.-H., Baik, J., Shin, H.-J., Kim, J.-H., Ryu, J.-H., & Han, S.-H. (2021). Neurotoxic Effects of Local Anesthetics on Developing Motor Neurons in a Rat Model. Journal of Clinical Medicine, 10(5), 901.

Kovacic, P., & Somanathan, R. (2012). Mechanism of Anesthetic Toxicity: Metabolism, Reactive Oxygen Species, Oxidative Stress, and Electron Transfer. International Scholarly Research Notices, 2011, e402906.

Levy, R. J. (2017). Carbon monoxide and anesthesia-induced neurotoxicity. Neurotoxicology and Teratology, 60, 50–58.

Li, J., Xiong, M., Nadavaluru, P. R., Zuo, W., Ye, J. H., Eloy, J. D., & Bekker, A. (2016). Dexmedetomidine attenuates neurotoxicity induced by prenatal propofol exposure. Journal of Neurosurgical Anesthesiology, 28(1), 51-64.

Ling, Y., Li, X., Yu, L., Liang, Q., Lin, X., Yang, X., ... & Zhang, Y. (2017). Sevoflurane exposure in postnatal rats induced long‑term cognitive impairment through upregulating caspase‑3/cleaved‑poly (ADP‑ribose) polymerase pathway. Experimental and Therapeutic Medicine, 14(4), 3824-3830.

Liu, X., Ji, J., & Zhao, G. Q. (2020). General anesthesia affecting on developing brain: evidence from animal to clinical research. Journal of Anesthesia, 34, 765-772.

Loftis, G. K., Collins, S., & McDowell, M. (2012). Anesthesia-induced neuronal apoptosis during synaptogenesis: A review of the literature. AANA Journal, 80(4), 291–298.

Loepke, A. W., & Soriano, S. G. (2020). Impact of pediatric surgery and anesthesia on brain development. Gregory's Pediatric Anesthesia, 1151-1181.

Lu, L. X., Yon, J.-H., Carter, L. B., & Jevtovic-Todorovic, V. (2006). General anesthesia activates BDNF-dependent neuroapoptosis in the developing rat brain. Apoptosis, 11(9), 1603–1615.

Ma, L.-H., Yan, J., Jiao, X.-H., Zhou, C.-H., & Wu, Y.-Q. (2022). The Role of Epigenetic Modifications in Neurotoxicity Induced by Neonatal General Anesthesia. Frontiers in Molecular Neuroscience, 15, 877263.

Mete, M., Aydemir, I., Tuglu, I. M., & Selcuki, M. (2015). Neurotoxic effects of local anesthetics on the mouse neuroblastoma NB2a cell line. Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission, 90(3), 216–222.

Montana, M. C., & Evers, A. S. (2017). Anesthetic Neurotoxicity: New Findings and Future Directions. The Journal of Pediatrics, 181, 279–285.

Nishimura, Y., Kanda, Y., Sone, H., & Aoyama, H. (2021). Oxidative Stress as a Common Key Event in Developmental Neurotoxicity. Oxidative Medicine and Cellular Longevity, 2021, e6685204.

Popić, J., Pešić, V., Milanović, D., Lončarević-Vasiljković, N., Smiljanić, K., Kanazir, S., & Ruždijić, S. (2015). Induction of TNF-α signaling cascade in neonatal rat brain during propofol anesthesia. International Journal of Developmental Neuroscience, 44, 22–32.

Ramirez-Lee, M. A., Talpos, J. C., & Walters, J. L. (2023). Chapter 37—Rodent models of anesthesia-induced developmental neurotoxicity☆. In C. R. Martin, V. B. Patel, & V. R. Preedy (Eds.), Handbook of Animal Models in Neurological Disorders (pp. 455–464).

Sarić, N., Hashimoto-Torii, K., Jevtović-Todorović, V., & Ishibashi, N. (2022). Nonapoptotic caspases in neural development and in anesthesia-induced neurotoxicity. Trends in Neurosciences, 45(6), 446–458.

Sekimoto, K., Tobe, M., & Saito, S. (2017). Local anesthetic toxicity: Acute and chronic management. Acute Medicine & Surgery, 4(2), 152–160.

Shi, Q., Cleeland, C. S., Klepstad, P., Miaskowski, C., & Pedersen, N. L. (2010). Biological pathways and genetic variables involved in pain. Quality of Life Research, 19, 1407-1417.

Stone, J. B., & DeAngelis, L. M. (2016). Cancer-treatment-induced neurotoxicity—focus on newer treatments. Nature Reviews Clinical oncology, 13(2), 92-105.

Stratmann, G. (2011). Review article: Neurotoxicity of anesthetic drugs in the developing brain. Anesthesia and Analgesia, 113(5), 1170–1179.

Useinovic, N., Maksimovic, S., Liechty, C., Cabrera, O. H., Quillinan, N., & Jevtovic-Todorovic, V. (2022). Systemic inflammation exacerbates developmental neurotoxicity induced by sevoflurane in neonatal rats. British Journal of Anaesthesia, 129(4), 555–566.

Vosoughian, M., Dahi, M., Dabir, S., Moshari, M., Tabashi, S., & Mosavi, Z. (2021). Effects of General Anesthesia Versus Spinal Anesthesia on Serum Cytokine Release After Cesarean Section: A Randomized Clinical Trial. Anesthesiology and Pain Medicine, 11(2), e111272.

Vutskits, L., & Davidson, A. (2023). Clinical investigations on anesthesia-induced developmental neurotoxicity: The knowns, the unknowns and future prospects. Best Practice & Research Clinical Anaesthesiology, 37(1), 40-51.

Wenzel, M., Leunig, A., Han, S., Peterka, D. S., & Yuste, R. (2021). Prolonged anesthesia alters brain synaptic architecture. Proceedings of the National Academy of Sciences, 118(7), e2023676118.

Wu, J., Bie, B., & Naguib, M. (2016). Epigenetic Manipulation of Brain-derived Neurotrophic Factor Improves Memory Deficiency Induced by Neonatal Anesthesia in Rats. Anesthesiology, 124(3), 624–640.

Wu, L., Zhao, H., Weng, H., & Ma, D. (2019). Lasting effects of general anesthetics on the brain in the young and elderly: “Mixed picture” of neurotoxicity, neuroprotection and cognitive impairment. Journal of Anesthesia.

Wu, X., Lu, Y., Dong, Y., Zhang, G., Zhang, Y., Xu, Z., ... & Xie, Z. (2012). The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β. Neurobiology of aging, 33(7), 1364-1378.

Xie, S., Yu, L., Zhou, M., Liu, L., Lei, D., & Han, C. (2020). Association between BDNF rs6265 polymorphisms and postoperative cognitive dysfunction in Chinese Han Population. Brain and Behavior, 10(10), e01800.

Yang, Y., Liu, T., Li, J., Yan, D., Hu, Y., Wu, P., ... & Hu, Z. (2024). General anesthetic agents induce neurotoxicity through astrocytes. Neural Regeneration Research, 19(6), 1299-1307.

Yang, M., & Wei, H. (2017). Anesthetic neurotoxicity: Apoptosis and autophagic cell death mediated by calcium dysregulation. Neurotoxicology and Teratology, 60, 59–62.

Zanghi, C. N., & Jevtovic-Todorovic, V. (2017). A holistic approach to anesthesia-induced neurotoxicity and its implications for future mechanistic studies. Neurotoxicology and Teratology, 60, 24–32.

Zhang, K., Yang, S., & Luo, C. (2018). TNF-alpha and TNF-R1 regulate bupivacaine-induced apoptosis in spinal cord dorsal root ganglion neuron. European Journal of Pharmacology, 833, 63–68.

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Published

2024-05-30

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Section

Review Article

How to Cite

Genetic Markers for Anesthesia-induced Neurotoxicity. (2024). Malaysian Journal of Human Genetics, 4(1), 24-30. https://mjhg.kk.usm.my/index.php/journal/article/view/44

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