Significance of Host Defence Genetics Initiative in Pneumonia
Keywords:
Pneumonia, streptococcus pneumoniae, pneumococcal disease, genetic diseasesAbstract
Pneumonia, a prevalent and life-threatening respiratory infection, continues to pose a significant global health challenge. This article provides a comprehensive review of recent advances in understanding the host defence mechanism of pneumonia. The genetic interaction between innate and adaptive immunity plays a vital role in the functioning of the human immune system. The range of genetic markers that influence an individual's response to the infection is one of the primary elements adding to the complexity of pneumonia. One of the most crucial things to consider when examining the genetics of immune activation is the signalling mechanisms initiating immunological responses. GWAS includes extensive analyses of DNA variations across the whole genome, allowing for the identification of genetic loci and potentially causative genes. Understanding the interactions between these genetic characteristics and the host's immune system is necessary to develop effective treatment approaches. Integrating genetic information with other characteristics, such as microbiological and environmental factors, is a crucial area of focus in pneumonia research. Advanced gene editing and therapeutic techniques have promising futures in pneumonia genetic research.
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